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You will gain more muscle taking steroids and not working out, than if you work out cleanly. If you use steroids, you will become a giant and probably never get down to your last 30 lbs.

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Many athletes use anabolic-androgenic steroids (aas) for physical enhancement but the magnitude of these gains and associated adverse effects has not been rigorously quantified. We aimed to examine the adverse effects of long-term use of aas, a compound that is currently available in both prescribed and nonprescribed forms. We report here the long-term clinical and histopathological effects of long-term (6 month) prolonged aas use in healthy male participants. We hypothesize that AAs could contribute to adverse long-term effects, both direct and indirect, such as increased oxidative stress and neurodegenerative disorders.

Results

AAS Dosage and Adverse Effects

In this study, we were unable to exclude the possibility that AAs caused an increase in the number of post-surgery acute renal injury (ANSI scores) or acute renal failure (ANSI score < 2, ANSI score ≥ 2) or both. Although we did not find any increase in the overall incidence of ANSI score ≥ 2 when assessing athletes' aas use over an extended period (n = 23 [10.2%]), it is possible that some of the athletes using aas were not as fit or were consuming a more potent form because of lower aas dosage or side effects. In addition, a large number of the participants (n = 60) did not have any long-term effects as determined by ANSI, although the ANSI score was not significantly different between patients with the most severely affected renal tissues (n = 18) or non-affected (n = 15) patients (Figure 2).

Fig. 2. View largeDownload slide Mean (±SEM) number of post-surgery acute renal injury (analyses: n = 45), ANSI score ≥ 2 (analysis: n = 43), ANSI score < 2 (analysis: n = 28), ANSI score ≥ 2 (analysis: n = 21), and ANSI score < 2 (analysis: n = 13), measured by ANSI at baseline (n = 40) prior to the study. Note that this figure does not

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