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PARTICIPANTS: Healthy subjects, ages 21-61 yr, were studied. INTERVENTIONS: CJC-1295 or placebo was administered sc in one of four ascending single doses in the first study and in two or three weekly or biweekly doses in the second study. MAIN OUTCOME MEASURES: The main outcome measures were peak concentrations and area under the curve of GH and IGF-I; standard pharmacokinetic parameters were used for CJC-1295. RESULTS: After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 d or more and in mean plasma IGF-I concentrations by 1. The estimated half-life of CJC-1295 was 5. After multiple CJC-1295 doses, mean IGF-I levels remained above baseline for up to 28 d. No serious adverse reactions were reported. CONCLUSIONS: Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 microg/kg, gp tren enanth 200 mg injectable steroids trenbolone enanthate. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent. J Clin Endocrinol Metab. Epub 2005 Dec 13. CONTEXT: Pulsatile GH secretion is considered important for many of the hormone’s physiological effects. Short-term GHRH infusions enhance GH pulsatility and increase IGF-I, but the short GHRH half-life limits its therapeutic use. A synthetic GHRH analog (CJC-1295) that binds permanently to endogenous albumin after injection (half-life = 8 d) stimulates GH and IGF-I secretion in several animal species and in normal human subjects and enhances growth in rats. OBJECTIVE: Our objective was to assess GH pulsatility after a single injection of CJC-1295 and determine which GH secretion parameters correlated to the increase in IGF-I production. METHODS: GH pulsatility was assessed by 20-min blood sampling during an overnight 12-h period in healthy 20- to 40-yr-old men before and 1 wk after injection of either 60 or 90 microg/kg CJC-1295. RESULTS: GH secretion was increased after CJC-1295 administration with preserved pulsatility. The frequency and magnitude of GH secretory pulses were unaltered. However, basal (trough) GH levels were markedly increased (7. CONCLUSIONS: CJC-1295 increased trough and mean GH secretion and IGF-I production with preserved GH pulsatility. The marked enhancement of trough GH levels by continuous GHRH stimulation implicates the importance of this effect on increasing IGF-I. Long-acting GHRH preparations may have clinical utility in patients with intact pituitary GH secretory capability. J Clin Endocrinol Metab. Epub 2006 Oct 3.
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GHRP-6 is a 1st generation GHRP and is primarily used in the BB’ing community for two reasons, which are 1) GH release and 2) Appetite stimulation. If one is considering using this peptide for GH release, the individual should consider whether or not the accompanying appetite stimulation is a beneficial or negative characteristic in their current circumstances. In individuals who struggle with appetite issues and have trouble eating enough food to meet their daily caloric requirements, this peptide can prove to be a great addition to their program. For those on contest diets or who are trying to lean out, they may want to forego this peptide in exchange for a GHRP absent of this effect. Common benefits of GH (GHRP-6) include: * Reductions in body fat * Increased lean mass. Common side effects of GH (GHRP-6) include: * Water retention * Tightness and/or carpel tunnel-like symptoms in the wrist/hand. Recommendations for use: * GHRP-6 should be administered on an empty stomach. 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