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One of the downsides and reasons that this is not a widely used steroid is that compared with other oral compounds, Proviron has lower bioavailability. Proviron has relatively weak androgenic and estrogenic effects compared with other steroids, and can actually provide some mild anti-estrogenic benefits. Mesterolone is unlikely to play a star role in any stack, but one big benefit it can have even in a bulking stack is to increase the amount of free and available hormones from other steroids in the stack because this compound binds strongly to SHGB which can boost circulating free testosterone. Proviron is useful for cutting as not only can it help harden the muscles, but can also enhance that same effect from the other steroids in your stack. It also encourages fat burning thanks to its androgen receptor binding. Being quite anti-estrogenic, Proviron discourages water retention. 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